朱雍,男,1981年出生,药物化学专业博士,副教授,硕士生导师。2002年本科毕业于安徽师范大学应用化学专业,2010年获得中国药科大学药物化学专业博士学位,同年留校任教于31399金沙娱场城有机化学教研室。2014年9月至2015年10月以访问学者身份在哈佛大学化学与化学生物学系进行科研工作。现主要研究方向为靶向抗肿瘤小分子药物的设计、合成、生物活性及作用机制研究。先后主持国家自然科学基金青年项目1项,教育部博士学科点基金新教师类项目1项,中央高校科研业务费2项。参与国家自然科学基金面上项目5项。申请国内专利7项,国际专利1项,授权5项。
联系方式:zy_cpu@163.com
近三年发表的主要论文:
1.Discovery of novel phenoxybenzamide analogues as Raf/HDAC dual inhibitors. Geng Aixin; Cui Hao; Zhang Liyuan; Chen Xin; Li Hongmei; Lu Tao*; Zhu Yong* Bioorganic & Medicinal Chemistry Letters, 2019, 29(13): 1605~1608.
2.ULTRAFAST AND DIASTEREOSELECTIVE SYNTHESIS OF 3-SPIROCYCLOPROPYL-2-OXINDOLES BEARING THREE CONTINUOUS ALL-CARBON QUATERNARY CENTERS. Aixin Geng; Hao Cui; Liyuan Zhang; Tao Lu*; Yong Zhu*;HETEROCYCLES, 2019, 98(5): 711~722.
3.Design, synthesis and biological evaluation of novel isoindolinone derivatives as potent histone deacetylase inhibitors. Xin Chen; Shuang Zhao; Hongmei Li; Xin Wang; Aixin Geng; Hao Cui; Tao Lu; Yadong Chen*; Yong Zhu*. European Journal of Medicinal Chemistry, 2019, 168: 110~122.
4.Rhodium-Catalyzed Arylative Transformations of Propargylic Diols: Dual Role of the Rhodium Catalyst. Xing Junhao#; Zhu Yong#; Lin Xiao; Liu Na; Shen Yue; Lu Tao; Dou Xiaowei*. Advanced Synthesis & Catalysis, 2018, 360(8): 1595~1599.
5.Design, synthesis and biological evaluation of urea-based benzamides derivatives as HDAC inhibitors.Yong Zhu; Xin Chen; Ting Ran; Jiaqi Niu; Shuang Zhao; Tao Lu; Weifang Tang*.Medicinal Chemistry Research. 2017, 26(11): 2879~2888.
6.Design, synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-c]quinazoline derivatives as novel phosphatidylinositol 3-kinase and histone deacetylase dual inhibitors. Yichao Wu; Weichen Dai; Xin Chen; Aixin Geng; Yadong Chen; Tao Lu*; Yong Zhu*. RSC Advances, 2017, 7(82): 52180~52186.