何华,药物分析学教授,博士生导师。长期从事本科生和研究生的教学工作。1999年4月赴法国巴黎第五大学进行体内手性药物分离分析等研究。承担国家、省部级、国际合作及企业合作科研项目四十多项,在Coordination Chemistry Reviews、Biosensors and Bioelectronics、Chemical Engineering Journal、Carbon、Trends in Analytical Chemistry、Food Chemistry、Microchimica Acta、Chemical Communications、Journal of Materials Chemistry、Talanta、Applied Clay Science、Journal of Chromatography A、ACS Omega、Journal of Pharmaceutical and Biomedical Analysis、Analyst、Chemical Physics Letters、Journal of Nanoscience and Nanotechnology、Journal of Luminescence、Spectroscopy、化学学报、化学进展、光谱学与光谱分析、分析化学、高分子学报、中国环境科学、药学学报、中国药科大学学报等国内外学术刊物上发表论文200余篇,其中SCI收载论文160余篇。编写《现代色谱分析》等教科书和教学参考书9本。申请专利15项。
研究方向为药物现代仪器分析、药物质量研究与评价和药物分析新材料与新技术。主要从事微量组分、主客体相互作用的分析方法研究、手性药物分离分析和分子模拟研究。特别关注体内药物和生物药物的分离分析及药物质量标准研究和制订。
主要学术兼职:国家食品药品监督管理局保健食品评审专家,国家863计划评审专家,教育部学位与研究生教育评审专家,国家科技奖励评审专家,江苏省食品药品监督管理局评审专家,农业部兽药评审专家,《Int. J. Biomed. Sci.》杂志编委,《J Food, Agri. Environ.》杂志助理编委。
主要学术成绩:
镧系离子探针在肿瘤早期诊断及抗肿瘤筛选中的应用
与国内外临床医药学专家和病理专家合作,开展了荧光光谱与临床医学的交叉研究。率先提出了以Tb-CPI为探针,用于肿瘤快速诊断和抗肿瘤药物筛选的新方法。发表相关研究文章10余篇。
拟除虫菊酯及其异构体环境行为基础研究
围绕拟除虫菊酯在环境的滞留、迁移、转化和归趋研究中的不足,开展了拟除虫菊酯及其异构体的环境行为研究。为了解菊酯类农药在环境中滞留、迁移、转化等行为, 正确评价其药效和环境安全性提供科学依据。发表相关研究文章5篇。
手性药物分离分析
采用手性固定相,反相高效液相色谱法直接拆分苯并二氮杂草类药物对映体,可用于苯并二氮杂草类药物对映体的分离测定和体内研究。同时,通过热力学参数的计算,对分离机理进行了研究。发表文章8篇。
分子印迹水相分离技术及其在药学中的应用
基于溶剂热法制备了粒径、形貌、饱和磁化率均可灵活调节的磁性碳纳米管,实现了材料的可控性制备,并对复合机理进行了探讨;在磁性碳纳米管表面进行乙烯化和环糊精化修饰,合成了两种新型的功能单体MCNTs@C=C和MCNTs@β-CD,在分子印迹反应中同时作为基质材料和功能单体,从而提高印迹容量和印迹反应效率;结合纳米技术和表面分子印迹技术,在磁性碳纳米管表面制备分子印迹材料,应用于复杂样品的前处理,实现了基质材料和分离模式的技术创新;将磁性碳纳米管表面分子印迹材料应用于毛细管电色谱领域,同时作为柱塞和固定相,克服填充型毛细管电色谱柱柱塞制备困难、手性拆分效能低的瓶颈;探讨了磁性碳纳米管的合成机理、磁场辅助毛细管电色谱的构建原理、分子印迹孔穴与环糊精的空腔协同识别机制,为相关工作的研究提供了理论基础。
以GTFX为模板分子,制备了一种新型的M-MIP(两亲性M-MIP),并用新的检测方法考察其两亲性,结果表明得到的纳米材料在水及生物体液中均具有较好的适应性;利用溶胶-凝胶法,在c-MMWCNTs的表面制备了Cu(II)印迹聚合物,研究了Cu(II)在材料表面的吸附行为。并将该聚合物应用于中药材中残留重金属离子的检测;采用计算机模拟技术选择合适的功能单体,合成了一种对表柔比星(EPI)具有选择性的新型的水相识别M-MIP,并应用于模板药物的吸附及体外的控释过程。
将差示紫外光谱法及逆向预测法结合,对特定目标分子的分子印迹体系进行系统化的筛选,同时得到最佳单体、交联剂及致孔剂。避免了计算机模拟筛选的盲目性,同时不需要进行大量、反复的实验,为分子印迹体系的筛选提供了一种简便快捷的新方法。
采用CS掺杂的Fe3O4作为载体,利用CS自身所携带的氨基进行链转移剂的修饰,避免了在Fe3O4表面进行功能化的步骤,一步法就可合成带氨基的Fe3O4,同时CS的引入降低了毒性,提高了Fe3O4@CS的亲水性。链转移剂的存在使得MIP的合成更具有可控性,所合成印迹层更为均一,有利于Fe3O4@CS@MIP对CBZ的特异性吸附。
针对传统方法所制备的印迹聚合物现存在的吸附位点包埋过深,造成选择性低,吸附 能力减弱等缺点,设计新型的功能单体,合成出具有印迹位点均一、高度亲和力、高度专属性和快速结合动力学的新型磁性分子印迹材料,拓宽了分子印迹技术的发展。
结合枝状分子的结构特点与印迹技术原理相结合,深入探讨分子印迹产生选择性的机理,探讨空穴与氢键对目标分子的协同作用,以此改善分子印迹选择性的缺陷,排除基质干扰,为分子印迹技术在复杂样品前处理技术开辟新理论。
发表文章50余篇。
近期发表的部分文章:
1.Hua He,et al, Anticancer loading and controlled release of novel water-compatible magnetic nanomaterials as drug delivery agents, coupled to a computational modeling approach, J. Mater. Chem. B, 2013, 1, 4099–4109.
2.Hua He et al,Mixed hemimicelle solid-phase extraction based on magnetic carbon nanotubes and ionic liquids for the determination of flavonoids, Carbon, 2014, 72: 274-286.
3.Hua He et al, Mixed hemimicelles solid-phase extraction based on ionic liquid-coated Fe3O4/SiO2 nanoparticles for the determination of flavonoids in bio-matrix samples coupled with high performance liquid chromatography, Journal of Chromatography A, 2014, 1324: 78–85.
4.Hua He,et al,Development of novel molecularly imprinted magnetic solid-phase extraction materials based on magnetic carbon nanotubes and their application for the determination of gatifloxacin in serum samples coupled with high performance liquid chromatography. Journal of Chromatography A, 2013, 1274, 44-53.
5.Hua He et al,Development of novel amphiphilic magnetic molecularly imprinted polymers compatible with biological fluids for solid phase extraction and physicochemical behavior study, Journal of Chromatography A 2013, 1317, 110-120.
6.Hua He et al,Preparation of core–shell magnetic ion-imprinted polymer by sol-gel process for selective extraction of Cu(II) from herbal medicines, Analyst, 2014, 139: 2459–2466.
7.Hua He et al,Preparation of molecularly imprinted polymers on the surface of magnetic carbon nanotubes with pseudo template for rapid simultaneous extraction of four fluoroquinolones in egg samples. Analyst, 2013, 138, 3287-3296.
8.Hua He et al, A sensitive LC–MS/MS method for simultaneous determination of amygdalin and paeoniflorin in human plasma and its application, Journal of Pharmaceutical and Biomedical Analysis, 2014, 92:160–164.
9.Hua He et al,Adsorption behavior of epirubicin hydrochloride on carboxylated carbon nanotubes, International Journal of Pharmaceutics, 2011, 405(1-2): 153-161.
10.Hua He et al,Single-step preparation of fluorescent carbon nanoparticles and their application as a fluorometric probe for quercetin, Microchim Acta., 2014, 181: 1309-1316.
11.Hua He et al,Magnetic carbon nanotubes: synthesis by a simple solvothermal process and application in magnetic targeted drug delivery system, J Nanopart Res, 2012, 14:984-996.
12.Hua He et al,Loading behavior of gatifloxacin in urine and lake water on a novel magnetic molecularly imprinted polymer used as extraction sorbent with spectrophotometric analysis. Journal of Separation Science, 2013, 36(5), 898-906.
13.Hua He et al, Carbon Nanotubes: Applications in Pharmacy and Medicine, Biomed Res Int. 2013, 578290.
14.Hua He et al, Label-free silver nanoparticles for the naked eye detection of entecavir, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 126: 178–183.
15.Hua He et al, Interaction of carboxylated single-walled carbon nanotubes with bovine serum albumin. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2013, 105: 45-51.
16.Hua He et al, Simultaneous extraction of anthracyclines from urine using water-compatible magnetic nanoparticles with dummy template coupled with high performance liquid chromatography, Analytical methods, 2014, 6:4421-4429.
17.Hua He et al,Interaction of amidated single-walled carbon nanotubes with protein by multiple spectroscopic methods, Journal of Luminescence, 2014, 145:125–131.
18.Hua He et al,Microwave-assisted one-step green synthesis of amino-functionalized fluorescent carbon nitride dots from chitosan. Luminescence, 2013, 28, 612-615.
19.Hua He et al,Microwave assisted one-step green synthesis of carbon nitride dots from ionic liquids and their application as novel fluorescence probe for quercetin determination. Journal of Luminescence, 2013, 140, 120-125.
20.Hua He, et al, Molecularly Imprinted Stationary Phase Prepared by Reverse Micro-emulsion Polymerization for Selective Recognition of Gatifloxacin in Aqueous Media, J. Chromatogr Sci, 2012, 50(6): 499-509.
21.Hua He et al,Chiral Separation of Ketoprofen on a Chirobiotic T Column and Its Chiral Recognition Mechanisms, Chromatographia, 2012, 75:1355–1363.
22.Hua He et al,The interaction between ketoprofen and bovine serum albumin by molecular simulation and spectroscopic methods. Spectroscopy, 2011, 26:337-348.
23.Hua He et al,Adsorption Behavior of Pazufloxacin Mesilate on Amino-Functionalized Carbon Nanotubes, Journal of Nanoscience and Nanotechnology, 2012, 12:1-9.
24.Hua He et al,Adsorption behavior and adsorption mechanism of Cu(II) ions on amino-functionalized magnetic nanoparticles, Trans. Nonferrous Met. Soc. China 2013, 23: 2657−2665.
25.何华等,羧基化多壁碳纳米管/Fe3 O4磁性复合材料对水中铜( II) 的吸附性能,新型炭材料(英文版)New Carbon Materials,2014, 29(4):15-25.
26.何华等,三种酸氧化法对多壁碳纳米管的功能化及其含氧官能团含量的比较研究,分析化学,2011,39(5):718-722.
27.何华等,离子液体双水相技术萃取头孢呋辛酯及其机理探究,分析化学,2012,40(8):1252-1256.
28.何华等,光谱法与分子模拟技术研究杨梅素与牛血清白蛋白的相互作用,化学学报,2012,70(2):143-150.
29.何华等,荧光光谱法研究共存碳纳米管对牛血清白蛋白与加替沙星相互作用的影响,光谱学与光谱分析,2011,31(1):149-153.
30.何华等,米托蒽醌与B-DNA相互作用的分子模拟,化学学报,2010,68(6): 551-556.
31.何华等,PAMAM树状大分子对酮基布洛芬溶解度的影响,高分子学报, 2010,7:876-883.
32.何华等,不同代 PAMAM 树状大分子与牛血清白蛋白的相互作用研究,化学学报,2010,68(17):1741-1748.
33.何华等,聚酰胺-胺树状大分子靶向给药系统的研究进展, 药学学报, 2011, 46 (5): 493−501.
34.何华等,纳米结构分子印迹聚合物及其在药物分析中的应用进展,分析化学,2012,40(8):1461-1468.
35.何华等,分子印迹水相分离技术及其在分析化学中的应用,化学进展,2011,2(10):2140-2150.
36.Hua He et al,Simultaneous extraction of anthracyclines from urine using water-compatible magnetic nanoparticles with a dummy template coupled with high performance liquid chromatography, Anal. Methods., 2014, 6(12): 4421-4429.
37.Hua He et al,Label-free silver nanoparticles for visual colorimetric detection of etimicin, Anal. Methods., 2014, 6, 7906-7911.
38.Hua He et al,Synthesis and analytical applications of molecularly imprinted polymers on the surface of carbon nanotubes: a review, Microchim Acta, 2015, 182: 893–908.
39.Hua He et al,Magnetic solid-phase extraction based on Fe3O4 nanoparticles retrieval of chitosan for the determination of flavonoids in biological samples coupled with high performance liquid chromatography, RSC Adv., 2014, 4, 64843–6485.
40.Hua He et al,Applications of magnetic surface imprinted materials for solid phase extraction of levofloxacin in serum samples,J. Mol. Recognit., 2015, 28, 277–284.
41.Hua He et al,Porous carbon quantum dots: one step green synthesis via L-cysteine and application in metal ions detection, RSC Adv., 2015, 5, 2039–2046.
42.Hua He et al, Colorimetric determination of o-phenylenediamine in water samples based on the formation of silver nanoparticles as a colorimetric probe, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2015, 140(5):328–333.
43.Hua He et al,Microwave-assisted synthesis of BSA-modified silver nanoparticles as a selective fluorescent probe for detection and cellular imaging of cadmium (II), Microchim Acta, 2015, 182:1255–1261.
44.Hua He et al,Adsorption behavior of a computer-aid designed magnetic molecularly imprinted polymer via response surface methodology, RSC Adv., 2015, 5, 61161–61169.
45.Hua He et al,One-step spontaneous synthesis of fluorescent carbon nanoparticles with thermosensitivity from polyethylene glycol,New J. Chem., 2015, 39, 7033–7039.
46.Hua He et al,Metal-organic framework based crystalline sponge method for structure analysis[J]. Trac Trends in Analytical Chemistry, 2018, 102:290-310.(IF=7.034)
47.Hua He et al,A regenerable sorbent composed of a zeolite imidazolate framework (ZIF-8), Fe3O4 and graphene oxide for enrichment of atorvastatin and simvastatin prior to their determination by HPLC[J].Microchimica Acta, 2018, 185 (2), 141-149. (IF=5.705)
48.Hua He et al,Calcium-doped fluorescent carbon nanoparticles: spontaneous thermal synthesis, pH-sensitive fluorescence off-on, and mechanism[J]. Sensors and Actuators B: Chemical,2018,266:594–602. (IF=5.667)
49.Hua He et al,One-pot sustainable synthesis of magnetic MIL-100(Fe) with novel Fe3O4 morphology and its application in heterogeneous degradation. Dalton Trans, 2018, 47 (10), 3417-3424. (IF=4.099)
50.Hua He et al,Colorimetric sensor for cimetidine in human urine based on D-xylose protected gold nanoparticles[J]. Analyst, 2018, 143:2369-2376. (IF=3.864)
51.Hua He et al, Mixed Hemimicelle Solid-Phase Extraction Based on Magnetic Halloysite Nanotubes and Ionic Liquids for the Determination and Extraction of Azo Dyes in Environmental Water Samples[J]. Journal of Chromatography A, 2018,1551,10-20. (IF=3.716)
52.Hua He et al, QbD Approach by Computer Aided Design and Response Surface Methodology for Molecularly Imprinted Polymer Based on Magnetic Halloysite Nanotubes for Extraction of Norfloxacin from Real Samples[J]. Talanta, 2018,184, 266-276. (IF=4.244)
53.Hua He et al, Preparation of Multifunctional PEG-graft-Halloysite Nanotubes for Controlled Drug Release, Tumor Cell Targeting, and Bio-imaging[J]. Colloids and Surfaces B: Biointerfaces, 2018, 170, 322–329. (IF=3.997)
54.Hua He et al, Halloysite nanotubes in analytical sciences and in drug delivery: A review [J]. Microchimica Acta, 2018, 185(8):389-421. (IF=5.705)
55.Hua He et al, Folic acid-conjugated chitosan oligosaccharide-magnetic halloysite nanotubes as a delivery system for camptothecin[J]. Carbohydrate Polymers, 2018, 197, 117–127. (IF=5.158)
56.Hua He et al, Novel mixed hemimicelles based on nonionic surfactant-imidazolium ionic liquid and magnetic halloysite nanotubes as efficient approach for analytical determination[J], Analytical and Bioanalytical Chemistry, 2018, 410(28): 7357-7371. (IF=3.307)
57.Hua He et al, Turn-on fluorescent detection of captopril in urine samples based on hydrophilic hydroxypropyl beta-cyclodextrin polymer, Analytical and Bioanalytical Chemistry[J], 2018, 410(28): 7373-7384. (IF=3.307)
58.Hua He et al, Silver nanoparticles for the visual detection of lomefloxacin in the presence of cystine[J], Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 2018, 205, 72-78. (IF=2.88)
59.Hua He et al, Colorimetric chiral recognition of D/L-phenylalanine based on triangular silver nanoplates[J], Amino Acids, 2018, 50(9): 1269-1278. (IF=2.906)
60.Hua He et al, Bifunctional monomer molecularly imprinted sol-gel polymers based on the surface of magnetic halloysite nanotubes as an effective extraction approach for norfloxacin[J], Applied Clay Science, 2018, 162, 409-417. (IF=3.641)
61.Hua He et al, Multifunctional core-shell silica microspheres and their performance in self-carrier decomposition, sustained drug release and fluorescent bioimaging[J], Journal of Solid State Chemistry, 2018, 263, 148-156. (IF=2.179)
62.Hua He et al, Label-Free Silver Nanoparticles for the Determination of Gentamicin[J], Journal of Nanoscience and Nanotechnology, 2018, 18(7): 4501-4506. (IF=1.354)
63.Hua He et al, Multifunctional carbon nanomateriels for camptothecine low-water soluble anticancer drug delivery[J], New Journal of Chemistry,2018, 42(2): 1326-1336. (IF=3.201)
64.Hua He et al, Preparation and performance study of MgFe2O4/metal–organic framework composite for rapid removal of organic dyes from water[J], Journal of Solid State Chemistry, 2018, 257, 40-48. (IF=2.179)
65.Hua He et al, Surface-imprinted beta-cyclodextrin-functionalized carbon nitride nanosheets for fluorometric determination of sterigmatomycin[J], Microchimica Acta, 2019, 186(12): 808-816. (IF=5.479)
66.Hua He et al, Visual and spectrophotometric detection of metformin based on the host-guest molecular recognition of cucurbit[6]uril-modified silver nanoparticles[J], Analytical and Bioanalytical Chemistry, 2019, 411(27): 7293-7302. (IF=3.286)
67.Hua He et al, Magnetite nanoparticles modified beta-cyclodextrin PolymerCoupled with KMnO4 oxidation for adsorption and degradation of acetaminophen[J], Carbohydrate Polymers, 2019, 222, 114972. (IF=6.044)
68.Hua He et al,MIP-coated Eu(BTC) for the fluorometric determination of lincomycin in eggs[J], Analytical Methods, 2019, 11(35): 4501-4510.(IF=2.378)
69.Hua He et al, Novel molecularly imprinted polymers on metal-organic frameworks as sensors for the highly selective detection of zearalenone in wheat[J], New Journal of Chemistry, 2019, 43(18): 7044-1050.(IF=3.069)
70.Hua He et al, Selective recognition and enrichment of carbamazepine in biological samples by magnetic imprinted polymer based on reversible addition-fragmentation chain transfer polymerization[J], Journal of Chromatography A, 2019, 1591, 62-70. (IF=3.858)
71.Hua He et al,One-step fabrication of a boric acid-functionalized lanthanide metal-organic framework as a ratiometric fluorescence sensor for the selective recognition of dopamine[J], New Journal of Chemistry, 2019, 43(3): 1291-1298. (IF=3.069)
72.Hua He et al, A method of detecting two tumor markers (p-hydroxybenzoic acid and p-cresol) in human urine using a porous magnetic
73.Hua He et al, Fluorescent probes based on macrocyclic hosts: Construction, mechanism and analytical applications[J], TrAC Trends in Analytical Chemistry, 2020, 133, 116086. (IF=9.801)
74.Hua He et al, Nanozymes based on metal-organic frameworks: Construction and prospects[J], TrAC Trends in Analytical Chemistry, 2020, 133, 116080. (IF=9.801)
75.Hua He et al, Cucurbiturils regulating Fe3O4-Au nanoparticles as a multi-functional platform for Cd2+ sensing and nitrocompound catalysis[J], Chemical Communications, 2020, 56(86): 13197-13200. (IF=5.996)
76.Hua He et al, Solid phase extraction based on magnetic carbon nitride/metal organic framework composite with high performance liquid chromatography for determination of tyrosine kinase inhibitors in urine samples[J], Analytical Methods, 2020, 12(39): 4798-4805. (IF=2.596)
77.Hua He et al, Establishment of extraction design space for ursolic acid from Paulowniae Flos based on the concept of quality by design[J], Phytochemical Analysis, 2020, 31(5): 535-544. (IF=2.772)
78.Hua He et al, Selective photodegradation of tetracycline by molecularly imprinted ZnO@NH2-UiO-66 composites[J], Chemical Engineering Journal, 2020, 390, 124614. (IF=13.273)
79.Hua He et al, Progress of gold nanomaterials for colorimetric sensing based on different strategies[J], TrAC Trends in Analytical Chemistry, 2020, 127, 115880. (IF=9.801)
80.Hua He et al, Selective recognition and enrichment of sterigmatocystin in wheat by thermo-responsive imprinted polymer based on magnetic halloysite nanotubes[J], Journal of Chromatography A, 2020, 1619, 460952. (IF=4.049)
81.Hua He et al, Magnetic hyperbranched molecularly imprinted polymers for selective enrichment and determination of zearalenone in wheat proceeded by HPLC-DAD analysis[J], Talanta, 2020, 209, 120555. (IF=5.339)
82.何华等人,衰减全反射傅立叶变换红外光度法快速测定西甲硅油中二甲硅油的含量,药物分析杂志, 2020, 40(04): 750-758.
83.Hua He et al, Ratiometric fluorescence sensing of metal-organic frameworks: Tactics and perspectives[J], Coordination Chemistry Reviews, 2020, 404, 213113. (IF=15.367)
84.Hua He et al, Visual Recognition and Detection of Clindamycin by Au@Ag Core-Shell Nanoparticles[J], Acs Omega, 2021, 6(22): 14260-14267. (IF=3.512)
85.Hua He et al, A structure-dependent ratiometric fluorescence sensor based on metal-organic framework for detection of 2,6-pyridinedicarboxylic acid[J]. Analytical and Bioanalytical Chemistry, 2021, 413(16): 4227-4236. (IF=4.142)
86.Hua He et al, ZnO nanorods/Fe3O4-graphene oxide/metal-organic framework nanocomposite: recyclable and robust photocatalyst for degradation of pharmaceutical pollutants[J], Environmental Science and Pollution Research, 2021, 28(17): 21799-21811. (IF=4.223)
87.Hua He et al, Simple and Efficient Detection Approach of Quercetin from Biological Matrix by Novel Surface Imprinted Polymer Based Magnetic Halloysite Nanotubes Prepared by a Sol-Gel Method[J], Journal of Chromatographic Science, 2021, 59(7): 681-695. (IF=1.618)
88.Hua He et al, Fluorescence determination of quercetin in food samples using polyhedron-shaped MOF@MOF(NUZ-8) based on NH2-UiO-66 and ZIF-8[J], Microchimica Acta, 2021, 188(1): 29. (IF=5.833)
89.Hua He et al, Nanozyme based on graphene oxide modified with Fe3O4, CuO, and cucurbit 6 uril for colorimetric determination of homocysteine[J], Microchimica Acta, 2021, 188(6): 207. (IF=5.833)
90.Hua He et al, Current review about design's impact on analytical achievements of magnetic graphene oxide nanocomposites[J], Trac-Trends in Analytical Chemistry, 2021, 137, 116211. (IF=12.296)
91.Hua He et al, Active metal single-sites based on metal-organic frameworks: construction and chemical prospects[J], New Journal of Chemistry, 2021, 45(3): 1137-1162. (IF=3.591)
92.Hua He et al, A boric acid-functionalized lanthanide metal-organic gel: A ratiometric fluorescence probe with rapid and sensitive detection of dopamine[J], Microchemical Journal, 2021, 169, 106579. (IF=4.821)
93.Hua He et al, Host-guest interaction between cucurbit[6]uril and chain amino acids[J], Chemical Physics Letters, 2021,783, 139039. (IF=2.328)
94.Hua He et al, Study on performance of mimic uricase and its application in enzyme-free analysis[J], Anal Bioanal Chem, 2021. (IF=4.142)
95.Hua He et al, A ratiometric fluorescence sensor based on metal-organic frameworks and quantum dots for detection of ascorbic acid[J], Optical Materials, 2021, 121, 111622. (IF=3.080)
96.Hua He et al, Colorimetric Detection of Benzoyl Peroxide in the Flour Samples Based on the Morphological Transition of Silver Nanoprisms[J], Food Analytical Methods, 2021. (IF=3.366)
97.Hua He et al, Surface molecularly imprinted polymers fabricated by differential UV-vis spectra and reverse prediction method for the enrichment and determination of sterigmatocystin[J], Food Chemistry, 2022, 367, 130715. (IF=7.514)
98.Hua He et al, Simple and fast detection of homocysteine by cucurbit[7]uril fluorescent probe based on competitive strategy[J], Chemical Physics Letters, 2022, 792, 139382. (IF=2.328)
99.Hua He et al, Novel composite nanomaterials based on magnetic molecularly imprinted polymers for selective extraction and determination of rutin in fruit juice[J], Food chemistry, 2022, 381, 132275. (IF=7.514)
100.Hua He et al, Synthesis and characterization of superparamagnetic graphene oxide assembled halloysite composites for extraction of rutin[J], Applied Clay Science, 2022, 217, 106397. (IF=5.467)
101.Hua He et al, Sensitive and selective detection of carbamazepine in serum samples by bionic double-antibody sandwich method based on cucurbit[7]uril and molecular imprinted polymers[J], Biosensors and Bioelectronics, 2022, 203, 114037.(IF=10.618)
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